MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology
نویسندگان
چکیده
منابع مشابه
MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology
Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as a fast-growing and highly invasive thyroid tumor that is unresponsive to surgery and radioiodine, blunting therapeutic efficacy. Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. ...
متن کاملMicroRNA deregulation in human thyroid papillary carcinomas.
MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in a wide range of basic processes such as cell proliferation, development, apoptosis and stress response. It has recently been found that they are also abnormally expressed in many types of human cancer. We analyzed the genome-wide miRNA expression profile in human thyroid papillary carcinomas (PTCs) using a microarray (miRNACHIP...
متن کاملMicroRNA biology in fungi
RNA processing is essential factor for synthesis of functional and structural proteins in eukaryote cells. In eukaryote organisms it will be initiated with transcription of DNA in nucleolus and terminated to mRNA translation in cytoplasm, finally mRNA degraded. Protein synthesis followed as different steps, includes 5' capping, poly adenylating, processing and transferring from nucleolus to cyt...
متن کاملDeregulation of microRNA expression in human thyroid carcinomas
Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been alr...
متن کاملMechanisms of MicroRNA Deregulation and MicroRNA Targets in Gastric Cancer.
Gastric cancer is a genetically heterogeneous disease that causes cancer-related deaths worldwide. Although many studies on this disease have been performed, the molecular mechanisms of gastric tumorigenesis, invasion, and metastasis have still not been identified. MicroRNAs (miRNAs) are endogenously coded small RNA molecules, 18-25 nucleotides in length, that regulate gene expression at the po...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2014
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2014/743450